It already has a nickname: Walkout Wednesday. Hardly a term of endearment but a reflection of just how widespread the disruption will be.
In fact, it's probably going to have the greatest impact of any strike day so far, because thousands of schools will be closed with parents stuck at home reliving the joys of working from home whilst trying to help their offspring to learn something.
Several unions have chosen to co-ordinate their action - so along with teachers - train drivers, university lecturers and civil servants are all going on strike.
Half a million people are expected to walk out. There will also be rallies, organised by the unions, to protest the government's plans to try and enforce a minimum service during strikes.
the government's trade union legislation.
So how will all of this affect you?
You can read more or watch this report about why people are taking strike action, and below you can find information on how it could affect you.
Upcoming strike action
Teachers in Scotland
- Teachers in Renfrewshire and Falkirk are on strike
- Members of the Educational Institute of Scotland (EIS) are taking action as part of an ongoing dispute over pay
Read more: Which schools will teachers' strikes affect?
Court staff on strike
- Members of the PCS union working as legal advisers and court associates in more than 80 courts across England and Wales are taking industrial action
- The union is taking the action due to a long-running dispute about a digital case management system known as Common Platform
There are currently no national strikes planned for this date
Teachers in Scotland
- Teachers in Aberdeenshire and Scottish Borders are on strike
- Members of the Educational Institute of Scotland (EIS) are taking action as part of an ongoing dispute over pay
Read more: Which schools will teachers' strikes affect?
Teachers in Scotland
- Teachers in Highlands and West Lothian are on strike
- Members of the Educational Institute of Scotland (EIS) are taking action as part of an ongoing dispute over pay
Read more: Which schools will teachers' strikes affect?
Civil servants
- About 100,000 civil servants in 124 government departments and other bodies are on strike in a dispute over pay and conditions
- Employees at the Department for Work and Pensions (DWP), the Driver & Vehicle Licensing Agency (DVLA), and the Department of Health and Social Care (DHSC) are among those taking part
Teachers
- In England and Wales, teachers who are members of the National Education Union (NEU) are on strike over pay
- The NEU is the largest education union in the UK and the disruption to schools is expected to be widespread
- In Scotland, teachers who are members of the Educational Institute of Scotland (EIS) in Clackmannanshire and Aberdeen are on strike as part of an ongoing dispute which is also over pay
Read more: Which schools will teachers' strikes affect in Scotland? | Where are teachers on strike in England and Wales?
Train drivers
- Train drivers who are members of the Aslef union are on strike
- Most train companies across England are affected
- Disruption is also expected on some services between England and Scotland, and between England and Wales
- Customers are encouraged to check their route before travelling
Read more: Train drivers to go on strike
University staff
- Thousands of staff at 150 universities across the UK are taking industrial action
- Academic staff and those in other professional roles including administrators, librarians and technicians are involved
Read more: Why are university staff striking?
Bus drivers on strike
- Bus drivers employed by Abellio in London are taking industrial action
- The routes affected are mostly in south and west London
Teachers in Scotland
- Teachers in Dundee and Argyll and Bute are on strike
- Members of the Educational Institute of Scotland (EIS) are taking action as part of an ongoing dispute over pay
Read more: Which schools will teachers' strikes affect?
Bus drivers on strike
- Bus drivers employed by Abellio in London are taking industrial action
- The routes affected are mostly in south and west London
Train drivers
- Train drivers who are members of the Aslef union are on strike
- Most train companies across England are affected
- Disruption is also expected on some services between England and Scotland, and between England and Wales
- Customers are encouraged to check their route before travelling
Read more: Train drivers to go on strike
Teachers in Scotland
- Teachers in South Lanarkshire and Western Isles are on strike
- Members of the Educational Institute of Scotland (EIS) are taking action as part of an ongoing dispute over pay
Read more: Which schools will teachers' strikes affect?
Bus drivers on strike
- Bus drivers employed by Abellio in London are taking industrial action
- The routes affected are mostly in south and west London
There are currently no national strikes planned for this date
There are currently no national strikes planned for this date
Nurses in England
- Members of the Royal College of Nursing (RCN) are taking industrial action over pay
- Life-preserving treatment must be provided, and all nurses in intensive and emergency care are expected to work
Read more: What do the strikes mean for patients?
Ambulance staff
- Ambulance staff in the GMB union are on strike in seven of the 10 English services and the national Welsh service, while Unite staff strike in four English services and Wales
- The strike affects non-life threatening calls only and people are advised to use the 999 service in an emergency
Read more: Why are ambulance staff striking?
Nurses in England on strike
- Members of the Royal College of Nursing (RCN) are taking industrial action over pay
- Life-preserving treatment must be provided, and all nurses in intensive and emergency care are expected to work
Read more: What do the strikes mean for patients?
Physiotherapists in Wales
- NHS physiotherapy staff in all Welsh Health Boards are on strike
- It is the first time physiotherapy staff in Wales have walked out over pay
Midwives in Wales
- Members of the Royal College of Midwives (RCM) in Wales are on strike from 0800 to 1600 GMT
- Services for women in labour or needing emergency care are not affected, according to the RCM
Read more: Midwives and physiotherapists to hold walkouts
There are currently no national strikes planned for this date
Physiotherapists take action
- NHS physiotherapy staff across England are striking over pay and staffing
- The Chartered Society of Physiotherapy says 4,200 members are involved
University staff
- Thousands of staff at 150 universities across the UK are taking industrial action
- Academic staff and those in other professional roles including administrators, librarians and technicians are involved
Read more: Why are university staff striking?
University staff
- Thousands of staff at 150 universities across the UK are taking industrial action
- Academic staff and those in other professional roles including administrators, librarians and technicians are involved
Read more: Why are university staff striking?
There are currently no national strikes planned for this date
There are currently no national strikes planned for this date
There are currently no national strikes planned for this date
University staff
- Thousands of staff at 150 universities across the UK are taking industrial action
- Academic staff and those in other professional roles including administrators, librarians and technicians are involved
Read more: Why are university staff striking?
Teachers in Wales
- Members of the National Education Union are on strike across the whole of Wales
- Many schools will close altogether and classes in some others will not run
Read more: Wales school strikes: Will my school be affected?
University staff
- Thousands of staff at 150 universities across the UK are taking industrial action
- Academic staff and those in other professional roles including administrators, librarians and technicians are involved
Read more: Why are university staff striking?
Ambulance staff
- Ambulance staff in the Unite union in Northern Ireland are on strike
- The strike affects non-life threatening calls only and people are advised to use the 999 service in an emergency
Read more: Why are ambulance staff striking?
University staff
- Thousands of staff at 150 universities across the UK are taking industrial action
- Academic staff and those in other professional roles including administrators, librarians and technicians are involved
Read more: Why are university staff striking?
Ambulance staff
- Ambulance staff in the Unite union in the West Midlands and in Northern Ireland are on strike
- The strike affects non-life threatening calls only and people are advised to use the 999 service in an emergency
Read more: Why are ambulance staff striking?
There are currently no national strikes planned for this date
There are currently no national strikes planned for this date
Teachers and university staff
Wednesday's action by teachers in England and Wales in the National Education Union, which has around half a million members, will hit about 23,400 schools.
But some schools may not decide until the morning whether to close, fully or partially, as it depends on how many staff choose to join the strike.
If you haven't heard then the advice is to send your children in as normal, as parents "have a legal duty to send their children to school unless they are unwell."
Schools have been advised to open for vulnerable pupils, key workers' children and those taking exams.
Some will open for certain classes only.
Children may be set work to do remotely - but striking teachers are not required to do so.
In addition, there is no automatic right for a parent affected by a lawful strike to claim compensation if they lose pay looking after a child.
The NEU, which is the largest British education union, has said a 5% government pay offer is the equivalent of a pay cut as the pace of price rises is running at more than 10%.
In Scotland, teachers who are members of the Educational Institute of Scotland (EIS) are continuing strikes over pay as part of a rolling wave of action. On Wednesday schools in Clackmannanshire and Aberdeen will be affected.
Tens of thousands of staff at 150 universities across the UK are also taking industrial action.
Teaching staff, administrators, librarians and technicians are some some of the people who will be on strike over pay, working conditions and pension cuts.
Previous strikes in November had caused little disruption, with lectures rescheduled and coursework deadlines extended, employers said.
Train drivers
If you're taking the train on Wednesday, Network Rail says "plan ahead and check your first and last train times".
Action by members of the Aslef train drivers' union and RMT unions means train companies across England are affected along with services to Scotland and Wales.
There will be no services at all on: Avanti West Coast; Chiltern Railways; CrossCountry; East Midlands Railway; Gatwick Express; Great Northern; Heathrow Express; London Northwestern Railway; Northern; Southeastern; Southern; Thameslink, South Western Railway Island Line services; TransPennine Express; West Midlands Railway.
Greater Anglia (including Stansted Express) and Great Western Railway are advising passengers not to use them, and LNER will run a reduced service.
South Western says it intends to run a service on the strike days, but has warned there may be short notice delays and cancellations due to difficulty getting drivers and trains to where they need to be.
Civil servants
About 100,000 civil servants from 124 government departments and other bodies are also on strike on Wednesday over pay and conditions.
Border Force operations will be affected, with possible delays for international arrivals at all UK air and maritime ports as well as at UK border controls in Calais, Dunkirk and Coquelles in northern France.
Travellers planning to enter the UK may face longer waiting times at border control.
Some driving tests may be affected, the DVSA said, adding that it had contacted affected candidates.
Organisations such as Ofsted, the Maritime and Coastguard Agency, and the Home Office will also have staff on strike.
Bus drivers
About 1,900 Abellio bus drivers in London are taking industrial action, mostly affecting routes in south and west London.
The latest strikes will go ahead on 1, 2, and 3 February in a dispute over pay, the Unite union said.
Some local bus services to Heathrow will be disrupted.
Additional reporting by Tom Espiner
Follow Zoe Conway on Twitter
How are you affected by the strikes? Are you taking part in strike action? You can email: haveyoursay@bbc.co.uk.
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