Madeleine Albright, a Czech immigrant who went on to become the first female secretary of state in US history, has died aged 84.
A long-time foreign policy veteran, Albright became America's top diplomat in 1997 during the Clinton government.
Often hailed as "a champion of democracy", Albright was instrumental in efforts to end ethnic cleansing in Kosovo.
Her death from cancer was confirmed by a State Department spokesman.
"The impact that she has had on this building is felt every single day," said Ned Price. "She was a trailblazer as the first female secretary of state, and quite literally opened doors for a large element of our workforce."
Among those to pay tribute to her after the announcement of her death was current Nato Secretary-General Jens Stoltenberg, who said Albright "was a force for freedom" and an "outspoken champion of Nato".
Former US President George W Bush said that Albright "understood first-hand the importance of free societies for peace in our world".
UK foreign secretary Liz Truss tweeted that the world "needs to stand by" Albright's values "more than ever".
Born Marie Jana Korbelova in Prague in 1937- in what was then Czechoslovakia - Albright was the daughter of a Czechoslovak diplomat who was forced into exile after the occupation of his country by Nazi Germany in 1939.
She moved to the United States in 1948, the same year her family applied for political asylum, arguing that they were unable to return home as opponents of their country's communist regime. She became a US citizen in 1957.
Albright went on to work at the White House during the Jimmy Carter administration and later as foreign policy adviser to a number of vice-presidential and presidential candidates.
Soon after Bill Clinton was inaugurated in 1993, Albright was appointed ambassador to the United Nations - her first diplomatic posting.
Madeleine Albright's story is quintessentially American.
A refugee who fled to the US with her family as a child, she made history by becoming the first woman to serve as secretary of state - and, as fourth in line for the presidency, the highest-ranking woman in US government up to that point.
As a diplomat, Albright helped shape the post-Soviet world during the Clinton administration, employing what she called "pragmatic idealism" to navigate uncharted geopolitical waters. That included, at times, an aggressive foreign policy that used US military might - in places like Iraq and the Balkans - when diplomacy failed.
The Nato bombing campaigns in the former Yugoslav states helped define a post-Soviet role for the western alliance at a time when Nato's future was very much in doubt.
Albright was also champion of Nato expansion, overseeing the addition of Poland, Hungary and Czechoslovakia in 1999 - a move whose repercussions are being keenly felt today.
In 1997, she became secretary of state, overcoming opposition from what some later termed the "anything but Albright" faction of the White House.
She became most famous during this time for her efforts to push the Clinton administration to intervene to stop ethnic cleansing in Kosovo being carried out by the Serbian regime of Slobodan Milosevic.
Some critics termed the subsequent Nato bombing campaign "Albright's War".
"I take full responsibility... for believing it was essential for us not to stand by and watch what Milosevic was planning to do," she said at the time. "We cannot watch crimes against humanity".
In 2012, then-President Barack Obama awarded her the Presidential Medal of Freedom - the highest award available to a civilian - for her work in the Balkans.
Just a month a month ago, on the eve of the invasion of Ukraine, Albright stepped back into the public spotlight with a New York Times editorial taking aim at Russian President Vladimir Putin, whom she first met soon after he took office in 2000.
"Ukraine is entitled to its sovereignty, no matter who its neighbours happen to be. In the modern era, great countries accept that, and so must Mr Putin," she wrote. "This is the message undergirding recent Western diplomacy.
"It defines the difference between a world governed by the rule of law and one answerable to no rules at all."
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