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A major incident has been declared after two trains collided, leaving several people injured.
The collision happened near London Road and involved a South Western Railway and a Great Western service.
About 12 people are thought to have been injured and one of the drivers is believed to be trapped in their cab.
The crash happened when one train hit an object in a tunnel, and the second train then collided with it due to signalling problems.
Dorset and Wiltshire Fire and Rescue declared the crash a "major incident", with police and the ambulance service in attendance.
Police and coastguard helicopters were also sent to the scene.
Other train services in the area, close to Fisherton Tunnel in the city, have been halted.
BBC reporter James Ingham said none of the passengers were believed to have been seriously injured. He added it was believed one train was on its side.
A Network Rail spokesperson said: "At around 19:00 GMT this evening, the rear carriage of the 17:08 Great Western Railway service from Portsmouth Harbour to Bristol Temple Meads derailed after striking an object on its approach to Salisbury station.
"The derailment knocked out all of the signalling in the area.
"Subsequently, the 17:20 South Western Railway service from London Waterloo to Honiton then collided with the Bristol train.
"There are reports of injuries and the emergency services are on site along with railway first responders."
The BBC is not responsible for the content of external sites. View original tweet on Twitter The BBC is not responsible for the content of external sites. View original tweet on TwitterBoth South Western Railway and Great Western Trains said their services had been stopped.
The Rail Accident Investigation Branch has also been called to the scene.
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